Parameter is not valid. Anti-TMC6 Antibody, - OriGene
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Anti-TMC6 Antibody

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SKU Description Amount Price Availability*  
TA306555
  • Rabbit Polyclonal EVER1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426702) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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OriGene Data

ImmunogenEVER1 antibody was raised against a 15 amino acid peptide from near the center of human EVER1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC, Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane channel-like 6 (TMC6), transcript variant 1
Alternative NameEV1; EVER1; EVIN1; LAK-4P
Database LinkNP_001120670
Entrez Gene 11322 Human
Entrez Gene 217353 Mouse
FunctionEpidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Related PathwayTransmembrane

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