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Home Antibody All anti-TMC6 antibodies

Anti-TMC6 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306554
  • Rabbit Polyclonal EVER1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426702) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TMC6 (NM_001127198)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenEVER1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human EVER1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens transmembrane channel-like 6 (TMC6), transcript variant 1
Alternative NameEV1; EVER1; EVIN1; LAK-4P
Database LinkNP_001120670
Entrez Gene 11322 Human
Entrez Gene 217353 Mouse
FunctionEpidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 ug/ml.

 

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