Home Antibody All anti-TLR8 antibodies
Also for TLR8 (NM_138636)
|TLR8 antibody was raised against a peptide corresponding to 16 amino acids near the middle of human TLR8.|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens toll-like receptor 8 (TLR8), transcript variant 2|
Entrez Gene 51311 Human
Entrez Gene 170744 Mouse
|Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). Like TLR7, TLR8 is localized to endosomal or lysosomal compartments (6) and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA (7). Human but not murine TLR8 confers responsiveness to the antiviral compound R-848 (8).|
|TransmembraneDruggable Genome Toll-like receptor signaling pathway|
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Western blot analysis of TLR8 in Daudi cell lysates with TLR8 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of TLR8 in Daudi cells with TLR8 antibody at 2 ug/mL.