Home Antibody All anti-TLR6 antibodies
Also for TLR6 (NM_006068)
|TLR6 antibody was raised against a peptide corresponding to 13 amino acids near the center of human TLR6.|
||ELISA, WB: 0.5 - 2 ug/ml, IHC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens toll-like receptor 6 (TLR6)|
|Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6).|
Toll-like receptor signaling pathway
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Western blot analysis of TLR6 in Jurkat cell lysate with TLR6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of TLR6 in Jurkat cells with TLR6 antibody at 2 ug/mL.