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Home Antibody All anti-TLR5 antibodies

Anti-TLR5 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306270 Rabbit Polyclonal TLR5 Antibody 100ug $325 3-7 Days
LC401126 TLR5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenTLR5 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens toll-like receptor 5 (TLR5)
Alternative NameMELIOS; SLE1; SLEB1; TIL3
Database LinkNP_003259
Entrez Gene 7100 Human
Entrez Gene 53791 Mouse
FunctionToll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-Α and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response (5).
Related PathwayTransmembraneDruggable Genome Toll-like receptor signaling pathwayPathogenic Escherichia coli infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TLR5 in THP-1 cell lysate with TLR5 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
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Immunocytochemistry of TLR5 in THP-1 cells with TLR5 antibody at 10 ug/mL.
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