Home Antibody All anti-TLR4 antibodies
Also for TLR4 (NM_003266)
|TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4.|
||ELISA, WB: 2.5 - 5 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens toll-like receptor 4 (TLR4), transcript variant 3|
|ARMD10; CD284; TLR-4; TOLL|
Entrez Gene 7099 Human
|Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappaB (4-6). Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis (7).|
|TransmembraneDruggable Genome Toll-like receptor signaling pathwayPathogenic Escherichia coli infection|
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Western blot analysis of TLR4 in PC-3 cell lysates with TLR4 antibody at (A) 2.5 and (B) 5 ug/mL.
Immunocytochemistry of TLR4 in K562 cells with TLR4 antibody at 2 ug/mL.