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Home Antibody All anti-TIRAP antibodies

Anti-TIRAP Antibody EPR3509

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307619
  • Rabbit monoclonal antibody against TIRAP(clone EPR3509)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422104) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for TIRAP (NM_001039661)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TIRAP was used as an immunogen.
Clone NameEPR3509 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3
Alternative NameBACTS1; Mal; MyD88-2; wyatt
Database LinkNP_001034750
FunctionMammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B along with other signaling pathways through the adaptor protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adaptor, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (2).
Related Pathway
Toll-like receptor signaling pathway

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WB Image
Western blot - Anti-TIRAP antibody [EPR3509]; All lanes : Anti-TIRAP antibody [EPR3509] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HUVEC cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 24 kDa.Observed band size : 30 kDa .

 

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