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Anti-TIRAP Antibody EPR3509
Also for TIRAP (NM_001039661)
|A synthetic peptide corresponding to residues in human TIRAP was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3|
|BACTS1; Mal; MyD88-2; wyatt|
|Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B along with other signaling pathways through the adaptor protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adaptor, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (2).|
Toll-like receptor signaling pathway
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Western blot - Anti-TIRAP antibody [EPR3509]; All lanes : Anti-TIRAP antibody [EPR3509] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HUVEC cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 24 kDa.Observed band size : 30 kDa .