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Home Antibody All anti-TIRAP antibodies

Anti-TIRAP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306133
  • Rabbit Polyclonal TIRAP Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422104) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TIRAP (NM_001039661)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTIRAP antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3
Alternative NameBACTS1; Mal; MyD88-2; wyatt
Database LinkNP_001034750
FunctionToll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7)
Related Pathway
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of TIRAP in human heart cell lysates with TIRAP antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of human heart cells using TIRAP antibody at 2 ug/ml.

 

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