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Anti-TIMELESS Antibody EPR5275
Also for TIMELESS (NM_003920)
|A synthetic peptide corresponding to residues near the C-terminus of human Timeless was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:200000; IHC-P: 1:100 - 1:250; ICC: 1:250 - 1:500
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens timeless circadian clock (TIMELESS)|
|hTIM; TIM; TIM1|
|Timeless is required for normal progression of S-phase, and is involved in the circadian rhythm autoregulatory loop. It natively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Timeless is also involved in cell survival after DNA damage or replication stress. It is specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Timeless plays an important role in epithelial cell morphogenesis and formation of branching tubules (1). |
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Western blot - Timeless antibody [EPR5275]; All lanes : Anti-Timeless antibody [EPR5275] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : JAR cell lysate.Lane 4 : BxPC-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 139 kDa.Observed band size : 150 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Timeless antibody [EPR5275]; Immunohistochemical analysis of paraffin-embedded Human colon tissue using TA310897 at a dilution of 1/100.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Timeless antibody [EPR5275]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using TA310897 at a dilution of 1/100.