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Home Antibody All anti-TIMELESS antibodies

Anti-TIMELESS Antibody EPR5275

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310897
  • Rabbit Monoclonal antibody against Timeless
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418350) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(2)
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Also for TIMELESS (NM_003920)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Timeless was used as an immunogen.
Clone NameEPR5275 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000 - 1:200000; IHC-P: 1:100 - 1:250; ICC: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens timeless circadian clock (TIMELESS)
Alternative NamehTIM; TIM; TIM1
Database LinkNP_003911
FunctionTimeless is required for normal progression of S-phase, and is involved in the circadian rhythm autoregulatory loop. It natively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Timeless is also involved in cell survival after DNA damage or replication stress. It is specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Timeless plays an important role in epithelial cell morphogenesis and formation of branching tubules (1).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Timeless antibody [EPR5275]; All lanes : Anti-Timeless antibody [EPR5275] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : JAR cell lysate.Lane 4 : BxPC-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 139 kDa.Observed band size : 150 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Timeless antibody [EPR5275]; Immunohistochemical analysis of paraffin-embedded Human colon tissue using TA310897 at a dilution of 1/100.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Timeless antibody [EPR5275]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using TA310897 at a dilution of 1/100.

 

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