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Anti-TG Antibody EPR3614
|A synthetic peptide corresponding to residues in human Thyroglobulin was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:20000; IP: 1:50; IHC-P: 1:250 - 1:500; ICC/IF: Use at an assay dependent concentration
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens thyroglobulin (TG)|
|Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4) (1, 2). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (2), and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis (3). |
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Western blot - Thyroglobulin antibody [EPR3614]; Anti-Thyroglobulin antibody [EPR3614] at 1/10000 dilution + Human thyroid lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 305 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Thyroglobulin antibody [EPR3614]; TA307372, at a 1/2500 dilution, staining Thyroglobulin in paraffin embedded Human papillary thyroid carcinoma tissue by Immunohistochemisty.