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Anti-TERF2 Antibody EPR3517(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TRF2(clone EPR3517(2))
100ul 325 3-7 Days
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Also for TERF2 (NM_005652)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TRF2 was used as an immunogen.
Clone NameEPR3517(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens telomeric repeat binding factor 2 (TERF2)
Alternative NameTRBF2; TRF2
Database LinkNP_005643
Entrez Gene 7014 Human
FunctionTelomeric repeat-binding factor 2 (TRF2) is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (1). Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protection, telomeres are no longer hidden from DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (1). TRF2 and TRF1, along with their interaction partners, reorganize the chromosome end into a T-loop, a protected structure, to hide the end of the chromosome (2). TRF2 can also recruit RAP1 to telomeres in order to inhibit non-homologous end joining (NHEJ) (3). In addition, TRF2 is ubiquitously expressed with high expression in the spleen, thymus, and colon (1).
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TRF2 antibody [EPR3517(2)]; All lanes : Anti-TRF2 antibody [EPR3517(2)] at 1/1000 dilution.Lane 1 : HT29 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 56 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRF2 antibody [EPR3517(2)]; TA307201 at 1/250 dilution staining TRF2 in Human spleen by Immunohistochemistry, Paraffin-embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - TRF2 antibody [EPR3517(2)]; TA307201 at 1/100 dilution staining TRF2 in HeLa cells by Immunofluorescence.


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