TCF13/TEF1 is a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor (1). It plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. TCF13/TEF1 binds specifically and cooperatively to the SPH and GT-IIC enhansons (2). It also binds M-CAT elements and regulates the development of cardiac, skeletal, and smooth muscles (3). Mutations in TCF13/TEF1 cause Sveinsson's chorioretinal atrophy (1).
Related Pathway
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