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Home Antibody All anti-TDP1 antibodies

Anti-TDP1 TRUEMAB Antibody clone 4H1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA503768
  • TDP1 mouse monoclonal antibody,clone 4H1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC413162) , 20ug
100ul 379 In Stock
CF503768
  • Carrier-free (BSA/glycerol-free) TDP1 mouse monoclonal antibody,clone 4H1
100ug $450 3-4 weeks
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WB(1)
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Also for TDP1 (NM_018319)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human TDP1(NP_060789) produced in HEK293T cell.
Clone Nameclone 4H1 IsotypeIgG1
Species ReactivityHuman Concentration0.78 mg/ml
Guaranteed Application *WB Suggested DilutionsWB 1:2000,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1
Alternative NameFLJ11090; MGC104252
Database LinkNP_060789
FunctionThe protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq].
Related Pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (RC214927, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1.

 

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