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Anti-TCF7 Antibody EPR2035


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against TCF-1 / TCF-7 (TCF7)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TCF-1 / TCF-7 was used as an immunogen.
Clone NameEPR2035 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:1000; ICC/IF: 1:100 - 1:250
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 3
Alternative NameTCF-1
Database LinkNP_001128323
Entrez Gene 6932 Human
Entrez Gene 21414 Mouse
FunctionTCF-1/TCF-7 is a transcriptional activator involved in T-cell lymphocyte differentiation, and it is necessary for the survival of CD4+ CD8+ immature thymocytes. As a HMG box transcription factor family member, it binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3'). (1, 2). Expression of TCF-1/TCF-7 is limited to T cells and NK cells (2). It also acts directly downstream of the canonical Wnt–ß-catenin signaling pathway. Non-phosphorylated ß-catenin accumulates in the cytoplasm, translocates to the nucleus and together with TCF-1/TCF-7, induces expression of Wnt (3).
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome Wnt signaling pathwayAdherens junctionMelanogenesisPathways in cancerColorectal cancerEndometrial cancerMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-TCF7 antibody [EPR2035]; All lanes : Anti-TCF7 antibody [EPR2035] at 1/1000 dilution.Lane 1 : Mouse thymus lysate.Lane 2 : Fetal thymus lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat ant-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 42 kDa.Observed band size : 25-55 kDa .
Immunocytochemistry/ Immunofluorescence - Anti-TCF7 antibody [EPR2035]; Immunofluorescent staining of HeLa cells labelling TCF7 with TA311086 at 1/100.


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