Anti-TCF3 Antibody,

Also for TCF3 (NM_001136139)

Gene Name	Homo sapiens transcription factor 3 (TCF3), transcript variant 2
Synonyms:	bHLHb21; E2A; E47; ITF1; TCF-3; VDIR
Immunogen	TCF3 antibody was raised against a 17 amino acid peptide near the amino terminus of human TCF3.
Buffer	PBS containing 0.02% sodium azide.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1 - 2 ug/ml
Background	The TCF3 gene, also called E2A, encodes two basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. These transcription factors are involved in mediating canonical Wnt signaling, which is very important in a diverse array of cellular functions such as stem cell proliferation, self-renewal, activation, fate determination, differentiation and aging and senescence. They bind beta-catenin and can act as transcriptional activators or repressors for Wnt target genes, and have been shown to regulate specific target genes during CNS development downstream of Wnt signaling. TCF3/Lef complexes are also known to play key roles in controlling cell fate lineages in multipotent skin stem cells.
Related Pathway	Delta-Notch Signaling Pathway Wnt Signaling Pathway

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WB Image

Western blot analysis of TCF3 in Human brain tissue lysate with TCF3 antibody at 1 µg/ml in (A) the absence and (B) presence of peptide blocking.

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Anti-TCF3 Antibody

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