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|Recombinant fragment corresponding to a region within amino acids 158 and 339 of TFIID (Uniprot ID#P20226)|
|Human (Predicted: Human, Mouse, Rat, Xenopus Tropicalis, Chicken, Chimpanzee, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Affinity purified by Protein A.
|Seq homology of immunogen across species: Human (100%), Mouse (100%), Rat (100%), Xenopus Tropicalis (100%), Chicken (100%), Chimpanzee (100%), Bovine (100%)
|Homo sapiens TATA box binding protein (TBP), transcript variant 1|
|GTF2D; GTF2D1; HDL4; SCA17; TFIID|
Entrez Gene 6908 Human
Entrez Gene 21374 Mouse
Entrez Gene 117526 Rat
|Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]|
|Transcription FactorsDruggable Genome Basal transcription factorsHuntington's disease|
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