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Home Antibody All anti-TBP antibodies

Anti-TBP Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308956 Rabbit Polyclonal antibody to TFIID (TATA box binding protein) 100ul $325 In Stock
LC401105 TBP HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 158 and 339 of TFIID (Uniprot ID#P20226)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Human, Mouse, Rat, Xenopus Tropicalis, Chicken, Chimpanzee, Bovine) Concentration7.36mg/ml
Guaranteed Application * Suggested Dilutions
Predicted MW Explanation 38kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Affinity purified by Protein A.
Note Seq homology of immunogen across species: Human (100%), Mouse (100%), Rat (100%), Xenopus Tropicalis (100%), Chicken (100%), Chimpanzee (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens TATA box binding protein (TBP), transcript variant 1
Alternative NameGTF2D; GTF2D1; HDL4; SCA17; TFIID
Database LinkNP_003185
Entrez Gene 6908 Human
Entrez Gene 21374 Mouse
Entrez Gene 117526 Rat
FunctionInitiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]
Related PathwayTranscription FactorsDruggable Genome Basal transcription factorsHuntington's disease

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