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Anti-TBK1 PHOSPHO Antibody EPR2867(2)
Also for TBK1 (NM_013254)
|A phospho specific peptide corresponding to residues surrounding serine 172 of human NAK/TBK1 was used as an immunogen. This antibody only detects NAK/TBK1 phosphorylated at serine 172.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens TANK-binding kinase 1 (TBK1)|
|NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).|
Toll-like receptor signaling pathway
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Western blot - NAK (phospho S172) antibody [EPR2867(2)]; All lanes : Anti-NAK (phospho S172) antibody [EPR2867(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.Predicted band size : 84 kDa.