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Anti-TBK1 Phospho Antibody EPR2867(2)
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Also for TBK1 (NM_013254)
|A phospho specific peptide corresponding to residues surrounding serine 172 of human NAK/TBK1 was used as an immunogen. This antibody only detects NAK/TBK1 phosphorylated at serine 172.|
|Human, Mouse, Rat
||IP: 1:10 - 100, WB: 1:1,000 - 10,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens TANK-binding kinase 1 (TBK1)|
|NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).|
Toll-like receptor signaling pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-NAK/TBK1 (pS172) RabMAb .