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Home Antibody All anti-TBC1D10C antibodies

Anti-TBC1D10C Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306446
  • Rabbit Polyclonal Carabin Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC404903) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TBC1D10C (NM_198517)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCarabin antibody was raised against a 17 amino acid peptide from near the amino terminus of human Carabin.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TBC1 domain family, member 10C (TBC1D10C), transcript variant 1
Alternative NameCARABIN; EPI64C
Database LinkNP_940919
FunctionAntigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Related Pathway

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WB Image
Western blot analysis of Carabin in human spleen tissue lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 ug/ml.

 

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