Home Antibody All anti-TAB2 antibodies
Anti-TAB2 Antibody Polyclonal
Also for TAB2 (NM_015093)
|TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2.|
||ELISA, IHC: 5 ug/ml
|TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TAB2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), transcript variant 1|
|CHTD2; MAP3K7IP2; TAB-2|
Entrez Gene 23118 Human
|TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.|
|Druggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathway|
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Immunohistochemistry of TAB2 in human brain tissue with TAB2 antibody at 5 ug/mL.