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Home Antibody All anti-ARID1A antibodies

Anti-ARID1A TRUEMAB Antibody clone OTI4D1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA806410 ARID1A mouse monoclonal antibody,clone OTI4D1 100ul $325 In Stock
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OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1986-2285 of human ARID1A (NP_006006) produced in E.coli.
Clone Nameclone OTI4D1 IsotypeIgG2a
Species ReactivityHuman Concentration1.00mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:500,
Predicted MW Explanation 241.9 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from cell culture supernatant by affinity chromatography

Reference Data

Target NameHomo sapiens AT-rich interaction domain 1A (ARID1A), transcript variant 1
Alternative NameB120; BAF250; BAF250a; BM029; C1orf4; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
Database LinkNP_006006
FunctionThis gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ARID1A (RC218151, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ARID1A.(1:500)
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