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Home Antibody All anti-DCC antibodies

Anti-DCC TRUEMAB Antibody Clone OTI5D10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA804517 DCC mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) 100ul $325 In Stock
LC417439 DCC HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF804517 Carrier-free (glycerol/BSA-free) DCC mouse monoclonal antibody, clone OTI5D10 (formerly 5D10) 100ug $450 3-4 Days
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OriGene Data

ImmunogenFull length human recombinant protein of human DCC (NP_005206) produced in HEK293T cell.
Clone NameClone OTI5D10 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000,
Predicted MW Explanation 158.3 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens DCC netrin 1 receptor (DCC)
Alternative NameCRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
Database LinkNP_005206
Entrez Gene 1630 Human
FunctionThis gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].
Related PathwayTransmembraneDruggable Genome Axon guidancePathways in cancerColorectal cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCC (RC218506, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCC.
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