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Home Antibody All anti-LMNA antibodies
KO-Validated

Anti-LMNA TRUEMAB Antibody Clone OTI3F6

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA803489 LMNA mouse monoclonal antibody, clone OTI3F6 (formerly 3F6) 100ul $325 In Stock
LC406886 LMNA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF803489 Carrier-free (BSA/glycerol-free) LMNA mouse monoclonal antibody, clone OTI3F6 (formerly 3F6) 100ug $450 3 Days
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OriGene Data

ImmunogenFull length human recombinant protein of human LMNA (NP_733821) produced in HEK293T cell.
Clone NameClone OTI3F6 IsotypeIgG2b
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB 1:2000,
Predicted MW Explanation 74 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens lamin A/C (LMNA), transcript variant 1
Alternative NameCDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC
Database LinkNP_733821
Entrez Gene 4000 Human
FunctionThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012].
Related PathwayDruggable Genome Hypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)Dilated cardiomyopathy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Equivalent amounts of cell lysates (10 ug per lane) of wild-type HeLa cells (WT, Cat# LC810HELA) and LMNA-Knockout hela cells (KO,Cat# LC810130) were separated by SDS-PAGE and immunoblotted with anti-LMNA monoclonal antibody TA803489. Then the blotted membrane was stripped and reprobed with anti-ß-actin (TA811000) as a loading control.(1:500)
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LMNA (RC204970, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LMNA.
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Western blot analysis of extracts (10ug) from 3 different cell lines by using anti-LMNA monoclonal antibody. (1:1000)
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