Anti-WNT3 Antibody, Clone 1G7

Also for WNT3 (NM_030753)

OriGene Data

Immunogen	Human recombinant protein fragment corresponding to amino acids 128-355 of human WNT3 (NP_110380) produced in E.coli.
Clone Name	Clone 1G7	Isotype	IgG2a
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:2000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens wingless-type MMTV integration site family, member 3 (WNT3)
Alternative Name	INT4
Database Link	NP_110380
Function	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008].
Related Pathway	Hedgehog signaling pathway Melanogenesis Wnt Signaling Pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WNT3 (RC211115, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-WNT3.

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-WNT3 mouse monoclonal antibody. (TA801867)

IHC Image

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-WNT3 mouse monoclonal antibody. (TA801867)

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Anti-WNT3 TrueMAB Antibody Clone 1G7

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data