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Home Antibody All anti-MDM2 antibodies

Anti-MDM2 TRUEMAB Antibody Clone 1E5

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA801705
  • MDM2 mouse monoclonal antibody,clone 1E5
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400855) , 20ug
100ul 325 In Stock
CF801705
  • Carrier-free (BSA/glycerol-free) MDM2 mouse monoclonal antibody,clone 1E5
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 119-438 of human MDM2 (NP_002383) produced in E.coli.
Clone NameClone 1E5 IsotypeIgG1
Species ReactivityHuman Concentration1.00 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:2000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens MDM2 oncogene, E3 ubiquitin protein ligase (MDM2), transcript variant 1
Alternative NameACTFS; hdm2; HDMX
Database LinkNP_002383
FunctionThis gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008].
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MDM2 (RC219518, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MDM2.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-MDM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA801705)

 

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