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Home Antibody All anti-BCL10 antibodies

Anti-BCL10 TRUEMAB Antibody Clone OTI6A8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA800451 BCL10 mouse monoclonal antibody, clone OTI6A8 (formerly 6A8) 100ul $325 In Stock
LC418351 BCL10 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF800451 Carrier-free (BSA/glycerol-free) BCL10 mouse monoclonal antibody, clone OTI6A8 (formerly 6A8) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(2)
IHC(2)

OriGene Data

ImmunogenFull length human recombinant protein of human BCL10 (NP_003912) produced in HEK293T cell.
Clone NameClone OTI6A8 IsotypeIgG1
Species ReactivityHuman , Dog Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:500, IHC 1:150,
Predicted MW Explanation 26.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 10 (BCL10)
Alternative Namec-E10; CARMEN; CIPER; CLAP; IMD37; mE10
Database LinkNP_003912
Entrez Gene 8915 Human
Entrez Gene 490183 Dog
FunctionThis gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BCL10 (RC208752, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BCL10.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-BCL10 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-BCL10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800451)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-BCL10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800451)
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