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Home Antibody All anti-F13A1 antibodies

Anti-F13A1 CONJUGATED Antibody Clone OTI1H2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA800305AM F13A1 mouse monoclonal antibody,clone 1H2, Biotinylated 100ul $600 1-2 Weeks
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OriGene Data

ImmunogenFull length human recombinant protein of human F13A1 (NP_000120) produced in HEK293T cell.
Clone NameClone OTI1H2 IsotypeIgG2a
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application * Suggested Dilutions
Predicted MW Explanation 79.2 kDa
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens coagulation factor XIII, A1 polypeptide (F13A1)
Alternative NameF13A
Database LinkNP_000120
FunctionThis gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq].
Related PathwaySecreted ProteinDruggable Genome Complement and coagulation cascades

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