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Home Antibody All anti-PPM1D antibodies

Anti-PPM1D GAT Antibody Polyclonal

Generated by Genomic Immunization


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA590650 Rabbit Polyclonal PPM1D Antibody 100ug $325 In Stock
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Also for PPM1D (NM_003620)
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OriGene Data

ImmunogenDNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration0.77153 mg/ml
Guaranteed Application *ELISA Suggested DilutionsELISA: 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D)
Alternative NamePP2C-DELTA; WIP1
Database LinkNP_003611
Entrez Gene 8493 Human
FunctionThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Related PathwayPhosphataseDruggable Genome p53 signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

ELISA: PPM1D Antibody


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