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Anti-STARD3 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for STARD3 (NM_006804)
|DNA immunization. This antibody is specific for the C Terminus Region of the target protein.|
||ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:10-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens StAR-related lipid transfer (START) domain containing 3 (STARD3), transcript variant 1|
|CAB1; es64; MLN64|
Entrez Gene 10948 Human
|The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN 64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN 64 are deleted, the resulting N-218 MLN 64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN 64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN 64 is similar to the organization of StAR. However, as MLN 64 never enters the mitochondria, the protease-resistant domain of MLN 64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.|
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Immunohistochemistry: STARD3 Antibody - Normal and malignant tissues generally displayed moderate to strong cytoplasmic immunoreactivity. Strong positivity was noted in both hepatocellular and cholangiocarcinomas though normal hepatocytes were moderately stained. Other strongly positive cancers included endometrial, urothelial, renal and gastro-intestinal cancers. Other cancers were generally moderately positive. Image and statement courtesy of the Human Protein Atlas (HPA).