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Home Antibody All anti-ANKRD11 antibodies
UltraMAB

Anti-ANKRD11 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590542
  • Rabbit Polyclonal ANKRD11 Antibody
100ug 325 Next Day
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WB(1)
IHC(2)
IF(1)
ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.22 mg/ml
Guaranteed Application *WB, ELISA, IHC, IF Suggested DilutionsELISA: 1:100-1:2000; IHC: 1:200; IF: 1:50
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens ankyrin repeat domain 11 (ANKRD11), transcript variant 2
Alternative NameANCO-1; ANCO1; LZ16; T13
Database LinkNP_037407
FunctionAnkyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22-24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.
Related Pathway

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WB Image
Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11; Lane 2: RT-4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilThis validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
ELISA Image
ELISA: ANKRD11 Antibody
IHC Image
Immunohistochemistry: ANKRD11 Antibody - Most of the normal cells showed strong nuclear positivity with an additional weaker cytoplasmic staining in many cases. Liver was weakly stained. Malignant cells displayed moderate to strong immunoreactivity. Image and statement courtesy of the Human Protein Atlas (HPA).
IHC Image
Immunohistochemical staining of human rectum shows strong nuclear and a weaker cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
IF Image
Immunofluorescent staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & cytoplasm.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

 

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