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Home Antibody All anti-PAX5 antibodies
UltraMAB

Anti-PAX5 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590505
  • Rabbit Polyclonal PAX5 Antibody
100ug 325 In Stock
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WB(1)
IHC(4)
ELISA(1)
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Also for PAX5 (NM_016734)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the Middle Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.26mg/ml
Guaranteed Application *WB, ELISA, IHC Suggested Dilutions WB 1:20000, IHC 1:150,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens paired box 5 (PAX5), transcript variant 1
Alternative NameALL3; BSAP
Database LinkNP_057953
Entrez Gene 5079 Human
FunctionThis gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAX5 (RC222785, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAX5.
ELISA Image
ELISA: PAX5 Antibody
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
IHC Image
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)

 

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