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Anti-PAX5 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for PAX5 (NM_016734)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
|WB, ELISA, IHC
|| WB 1:20000, IHC 1:150,ELISA 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens paired box 5 (PAX5), transcript variant 1|
Entrez Gene 5079 Human
|This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.|
|Transcription Factors |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAX5 (RC222785, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAX5.
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-PAX5 Rabbit Polyclonal antibody. (TA590505)