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Anti-ASPM GAT Antibody Polyclonal
UltraMAB Antibodies - Validated with 10K Protein Chip
Also for ASPM (NM_018136)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|ELISA, IHC, IF
||ELISA: 1:100-1:2000; IHC: 1:200; IF: 1:50
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody. (Protein A or G Sepharose)
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ASPM), transcript variant 1|
|ASP; Calmbp1; MCPH5|
|The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002). The mouse gene Aspm is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.[supplied by OMIM]|
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Immunohistochemistry: ASPM Antibody - Most of the normal tissues displayed moderate cytoplasmic positivity which was occasionally accompanied with nuclear staining. Strong cytoplasmic staining was seen in gall bladder and in stomach while adrenal cortex, hepatocytes and bone marrow poietic cells also showed strong nuclear positivity. Neuronal and lymphoid tissues were generally weakly stained or negative. Malignant tissues exhibited weak to moderate cytoplasmic immunoreactivity. Malignant carcinoids, lymphomas, head & neck, thyroid, testis and urothelial cancers were mainly weakly stained or negative. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human liver shows strong nuclear and cytoplasmic positivity in hepatocytes.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-2 OS shows positivity in plasma membrane & cytoplasm.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.