Home Antibody All anti-ULBP2 antibodies
Anti-ULBP2 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for ULBP2 (NM_025217)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
|WB, ELISA, IHC
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:1500
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens UL16 binding protein 2 (ULBP2)|
|ALCAN-alpha; N2DL2; NKG2DL2; RAET1H|
Entrez Gene 80328 Human
|ULBP2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.|
|Secreted ProteinTransmembraneDruggable Genome Natural killer cell mediated cytotoxicity|
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Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11; Lane 2: RT-4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilThis validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunohistochemical staining of human stomach shows cytoplasmic positivity in a subset of inflammatory cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.