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Anti-CD276 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for CD276 (NM_025240)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|ELISA, IHC, IF
||ELISA: 1:100-1:2000; IHC: 1:200; IF: 1:200
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens CD276 molecule (CD276), transcript variant 2|
|4Ig-B7-H3; B7-H3; B7H3; B7RP-2|
|Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).|
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Immunohistochemistry: CD276 Antibody - Most normal tissues displayed moderate cytoplasmic and occasional membranous immunoreactivity. Strong membranous expression was observed in the prostate gland. Basal layers of squamous epithelia showed moderate cytoplasmic positivity. Most cases of tumors demonstrated moderate cytoplasmic staining often combined with membranous immunoreactivity. Squamous cell carcinomas and adenocarcinomas of prostate and endometrium demonstrated strong membranous staining. A majority of cases in malignant lymphomas, stomach and pancreatic cancers were weakly stained or negative. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human prostate shows strong positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-251MG shows no positivity.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.