Home Antibody All anti-PPFIA1 antibodies
Anti-PPFIA1 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for PPFIA1 (NM_177423)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
|WB, ELISA, IHC
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:10-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1), transcript variant 1|
|LIP.1; LIP1; LIPRIN|
|This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions.May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane. possibly regulating their interaction with the extracellular environment and their association with substrates.|
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Western Blot: Liprin alpha 1 Antibody - Samples: Lane 1, Marker: 250, 130, 95, 72, 55, 36, 28, 17, 11 Lane 2, RT-4 Lane 3, U-251MG sp Lane 4, Human Plasma Lane 5, Liver Lane 6, Tonsil , Target weight: 136, 134 (splice variants) Validation score: 2 Validation description: Supportive - Band of predicted size in kDa (+/-20%) with additional bands present.
Immunohistochemistry: Liprin alpha 1 Antibody - Most of the normal tissues displayed moderate cytoplasmic positivity which was occasionally accompanied with nuclear staining. Strong cytoplasmic staining was found in gastro-intestinal tract, gall bladder and endocrine glands. Malignant tissues generally exhibited moderate cytoplasmic immunoreactivity. A few cases of colo-rectal, endometrial, gastric and pancreatic cancers revealed strong staining while many skin cancers were weakly stained. Image and statement courtesy of the Human Protein Atlas (HPA).