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Home Antibody All anti-PRCC antibodies
UltraMAB

Anti-PRCC GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA590344 Rabbit Polyclonal PRCC Antibody 100ug $325 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(3)
IHC(13)
ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman , Monkey , Mouse Concentration1.14mg/ml
Guaranteed Application *WB, ELISA, IHC Suggested Dilutions WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens papillary renal cell carcinoma (translocation-associated) (PRCC), transcript variant 2
Alternative NameMGC17178; MGC4723; RCCP1; TPRC;proline-rich protein PRCC; MGC4723; RCCP1; TPRC; OTTHUMP00000038719; papillary renal cell carcinoma translocation-associated gene product; papillary renal cell carcinoma (translocation-associated)
Database LinkNP_955448
Entrez Gene 5546 Human
Entrez Gene 94315 Mouse
Entrez Gene 718660 Monkey
FunctionIn a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRCC (RC223284, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRCC.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PRCC polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Western Blot: PRCC Antibody
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ELISA: PRCC Antibody
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Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-PRCC Rabbit Polyclonal antibody. (TA590344)
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