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Anti-PRCC GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for PRCC (NM_199416)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:250-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens papillary renal cell carcinoma (translocation-associated) (PRCC), transcript variant 2|
|MGC17178; MGC4723; RCCP1; TPRC;proline-rich protein PRCC; MGC4723; RCCP1; TPRC; OTTHUMP00000038719; papillary renal cell carcinoma translocation-associated gene product; papillary renal cell carcinoma (translocation-associated)|
|In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.|
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