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Anti-ITM2C GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for ITM2C (NM_030926)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|| WB 1:20000,ELISA 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens integral membrane protein 2C (ITM2C), transcript variant 1|
|BRI3; BRICD2C; E25; E25C; ITM3|
|ITM2C is a negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. ITM2C may also play a role in TNF-induced cell death and neuronal differentiation By similarity.|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITM2C (RC200947, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITM2C.