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Anti-CCL2 GAT Antibody Polyclonal
UltraMAB Antibodies - Validated with 10K Protein Chip
Also for CCL2 (NM_002982)
|DNA immunization. This antibody is specific for the entire range of the target protein.|
||ELISA: 1:100-1:2000; IHC: 1:125
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody. (Protein A or G Sepharose)
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens chemokine (C-C motif) ligand 2 (CCL2)|
|GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF|
|Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.|
Cytokine-cytokine receptor interaction
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Immunohistochemistry: MCP1 Antibody - Strong cytoplasmic positivity with additional staining of luminal membranes was seen in mucus-producing cells of the gastro-intestinal tract. Cells of the CNS and lymphoid tissues were in general negative, except for mast cells, which were strongly positive. In malignant tissues, mucin secreting colo-rectal carcinomas and mucinous cystadenocarcinomas of ovary exhibited strong cytoplasmic staining with additional positivity of luminal membranes. Few other adenocarcinomas were strongly stained in cytoplasm. Malignant gliomas, lymphomas and renal cancers were mainly negative. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.