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Anti-PTPRC TRUEMAB Antibody Clone OTI3E3
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PTPRC (NM_002838)
|Full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell.|
|WB, IF, FC
|| WB 1:400~8000, IF 1:100, FLOW 1:50,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1|
|B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200|
Entrez Gene 5788 Human
|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]. |
|ES Cell Differentiation/IPSTransmembranePhosphataseDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayFc gamma R-mediated phagocytosisPrimary immunodeficiency|
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PTPRC monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
HEK293T cells lysate (5 ug, left lane) and full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell (5 ug, right lane)were separated by SDS-PAGE and immunoblotted with anti-PTPRC.
Immunofluorescent staining of HeLa cells using anti-PTPRC mouse monoclonal antibody (TA506545).
Flow cytometric Analysis of Jurkat cells, using anti-PTPRC antibody(TA506545),(Red), compared to a nonspecific negative control antibody,(Blue).