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Anti-PIK3C2B TRUEMAB Antibody Clone OTI2G3
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for PIK3C2B (NM_002646)
|Full length human recombinant protein of human PIK3C2B(NP_002637) produced in HEK293T cell.|
|WB, IHC, IF
|| WB 1:2000~4000, IHC 1:150, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (PIK3C2B)|
Entrez Gene 5287 Human
|The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]. |
|Druggable Genome Inositol phosphate metabolismMetabolic pathwaysPhosphatidylinositol signaling system|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PIK3C2B (RC218354, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PIK3C2B.
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PIK3C2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506011)
Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-PIK3C2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506011)
Anti-PIK3C2B mouse monoclonal antibody (TA506011) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PIK3C2B(RC218354).