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Home Antibody All anti-MAP2K2 antibodies

Anti-MAP2K2 TRUEMAB Antibody Clone OTI1A2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA505680 MAP2K2 (MEK2 ) mouse monoclonal antibody, clone OTI1A2 (formerly 1A2) 100ul
30ul
$379 In Stock
LC403069 MAP2K2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505680 Carrier-free (BSA/glycerol-free) MAP2K2 mouse monoclonal antibody, clone OTI1A2 (formerly 1A2) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)
IHC(6)
IF(1)
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Also for MAP2K2 (NM_030662)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human MAP2K2(NP_109587) produced in HEK293T cell.
Clone NameClone OTI1A2 IsotypeIgG2a
Species ReactivityHuman , Dog , Rat , Monkey , Mouse Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:200~4000, IHC 1:150, IF 1:100,
Predicted MW Explanation 44.2 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2)
Alternative NameCFC4; MAPKK2; MEK2; MKK2; PRKMK2
Database LinkNP_109587
Entrez Gene 5605 Human
Entrez Gene 26396 Mouse
Entrez Gene 58960 Rat
Entrez Gene 721821 Monkey
Entrez Gene 611939 Dog
FunctionThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayVascular smooth muscle contractionVEGF signaling pathwayGap junctionToll-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAP2K2 (RC201827, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MAP2K2.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-MAP2K2 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505680)
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Anti-MAP2K2 mouse monoclonal antibody (TA505680) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MAP2K2(RC201827).
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