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Anti-MAP2K3 TRUEMAB Antibody Clone OTI6C6
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for MAP2K3 (NM_145109)
|Full length human recombinan protein of human MAP2K3(NP_659731) produced in HEK293T cell.|
|WB, IHC, IF
|| WB 1:2000, IHC 1:150, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B|
|MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2|
Entrez Gene 5606 Human
|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]. |
|Protein KinaseTranscription FactorsDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayFc epsilon RI signaling pathwayGnRH signaling pathwayAmyotrophic lateral sclerosis (ALS)|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAP2K3 (RC207115, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MAP2K3.
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-MAP2K3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505644)
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MAP2K3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505644)
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-MAP2K3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505644)
Anti-MAP2K3 mouse monoclonal antibody (TA505644) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MAP2K3(RC207115).