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Home Antibody All anti-CDKN2B antibodies

Anti-CDKN2B TRUEMAB Antibody clone 3E4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA505166
  • CDKN2B (p15 INK4b) mouse monoclonal antibody, clone 3E4
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417638) , 20ug
100ul $325 In Stock
CF505166
  • Carrier-free (BSA/glycerol-free) CDKN2B mouse monoclonal antibody,clone 3E4
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
FC(1)
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Also for CDKN2B (NM_004936)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human CDKN2B(NP_004927) produced in HEK293T cell.
Clone Nameclone 3E4 IsotypeIgG1
Species ReactivityHuman Concentration1.00 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB 1:2000, FLOW 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1
Alternative NameCDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Database LinkNP_004927
FunctionThis gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq].
Related Pathway
Cell cycle
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2B (RC204895, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2B.
FC Image
HEK293T cells transfected with either RC204895 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-CDKN2B antibody(TA505166), and then analyzed by flow cytometry.

 

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