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Home Antibody All anti-APP antibodies

Anti-APP TRUEMAB Antibody Clone OTI7A10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA505012 APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI7A10 (formerly 7A10) 100ul $325 In Stock
LC424694 APP HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505012 Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone OTI7A10 (formerly 7A10) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(2)

OriGene Data

ImmunogenFull length human recombinant protein of human APP(NP_000475) produced in HEK293T cell.
Clone NameClone OTI7A10 IsotypeIgG2b
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:1000, IHC 1:150,
Predicted MW Explanation 85.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_000475
Entrez Gene 351 Human
FunctionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (RC221339, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505012)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505012)
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