Anti-MME Antibody, Clone 3D11

Also for MME (NM_007287)

OriGene Data

Immunogen	Full length human recombinant protein of human MME(NP_009218) produced in HEK293T cell.
Clone Name	Clone 3D11	Isotype	IgG2a
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:2000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens membrane metallo-endopeptidase (MME), transcript variant 1bis
Alternative Name	CALLA; CD10; NEP; SFE
Database Link	NP_009218
Function	This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq].
Related Pathway	Hematopoietic cell lineage

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MME (RC223061, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MME.

IHC Image

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-MME mouse monoclonal antibody. (TA504507)

IHC Image

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-MME mouse monoclonal antibody. (TA504507)

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-MME TrueMAB Antibody Clone 3D11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data