Home Antibody All anti-CYP17A1 antibodies
Anti-CYP17A1 TRUEMAB Antibody Clone 3F12
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for CYP17A1 (NM_000102)
|Full length human recombinant protein of human CYP17A1(NP_000093) peoduced in HEK293T cell.|
|| WB 1:500,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)|
|CPT7; CYP17; P450C17; S17AH|
Entrez Gene 1586 Human
|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]. |
|P450Druggable Genome C21-Steroid hormone metabolismMetabolic pathways|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CYP17A1 (RC209042, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CYP17A1.