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Home Antibody All anti-BTRC antibodies

Anti-BTRC TRUEMAB Antibody clone 1A4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA502524
  • BTRC (Beta TRCP) mouse monoclonal antibody, clone 1A4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403255) , 20ug Explanation
100ul 325 In Stock
CF502524
  • Carrier-free (BSA/glycerol-free) BTRC mouse monoclonal antibody, clone 1A4
100ug $450 3-4 weeks
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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WB(1)
IF(1)

OriGene Data

ImmunogenHuman fragment corresponding to amino acids 52-354 of human BTRC (NP_378663) produced in E.coli.
Clone Nameclone 1A4 IsotypeIgG1
Species ReactivityHuman Concentration0.51 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB 1:500, IF 1:100,
Predicted MW Explanation 68.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 1
Alternative NameBETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Database LinkNP_378663
Entrez Gene 8945 Human
FunctionThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq].
Related PathwayDruggable Genome Oocyte meiosisUbiquitin mediated proteolysisWnt signaling pathwayHedgehog signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTRC (RC207025, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTRC.
IF Image
Anti-BTRC mouse monoclonal antibody (TA502524) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BTRC(RC207025).

 

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