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Anti-GBA3 TRUEMAB Antibody Clone OTI3E8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA502516 GBA3 mouse monoclonal antibody, clone OTI3E8 (formerly 3E8) 100ul $325 In Stock
LC402815 GBA3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF502516 Carrier-free (BSA/glycerol-free) GBA3 mouse monoclonal antibody, clone OTI3E8 (formerly 3E8) 100ug $450 3-4 weeks
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WB(1)
IHC(3)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1-150 and 370-469 of human GBA3(NP_066024) produced in E.coli.
Clone NameClone OTI3E8 IsotypeIgG1
Species ReactivityHuman Concentration0.74 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:2000, IHC 1:150,
Predicted MW Explanation 53.5 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens glucosidase, beta, acid 3 (gene/pseudogene) (GBA3), transcript variant 1
Alternative NameCBG; CBGL1; GLUC; KLRP
Database LinkNP_066024
Entrez Gene 57733 Human
FunctionGBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).[supplied by OMIM].
Related Pathway Cyanoamino acid metabolismStarch and sucrose metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GBA3 (RC211035, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GBA3.
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-GBA3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502516)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-GBA3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502516)
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Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-GBA3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502516)
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