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Anti-GALE TRUEMAB Antibody Clone OTI1C4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA502146 GALE mouse monoclonal antibody, clone OTI1C4 (formerly 1C4) 100ul $379 In Stock
LC424739 GALE HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF502146 Carrier-free (BSA/glycerol-free) GALE mouse monoclonal antibody, clone OTI1C4 (formerly 1C4) 100ug $450 3-4 weeks
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WB(3)
IHC(9)

OriGene Data

ImmunogenFull length human recombinant protein of human GALE (NP_000394) produced in HEK293T cell.
Clone NameClone OTI1C4 IsotypeIgG1
Species ReactivityHuman , Dog , Rat , Monkey Concentration0.6 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:500~2000, IHC 1:150,
Predicted MW Explanation 38.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1
Alternative NameSDR1E1
Database LinkNP_000394
Entrez Gene 2582 Human
Entrez Gene 114860 Rat
Entrez Gene 710553 Monkey
Entrez Gene 100855555 Dog
FunctionThis gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome Galactose metabolismAmino sugar and nucleotide sugar metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GALE (RC201561, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GALE.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-GALE monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-GALE monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen).
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146)
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