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Home Antibody All anti-ADSL antibodies

Anti-ADSL TRUEMAB Antibody Clone OTI2D10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501810 ADSL (Adenylosuccinate Lyase) mouse monoclonal antibody, clone OTI2D10 (formerly 2D10) 100ul $379 In Stock
LC424970 ADSL HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501810 Carrier-free (BSA/glycerol-free) ADSL mouse monoclonal antibody, clone OTI2D10 (formerly 2D10) 100ug $450 3-4 weeks

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(2)
IHC(9)
FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human ADSL (NP_000017) produced in HEK293T cell.
Clone NameClone OTI2D10 IsotypeIgG1
Species ReactivityHuman, Dog, Rat, Monkey Concentration0.55 mg/ml
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB 1:500~2000, IHC 1:150, FLOW 1:100
Predicted MW Explanation 54.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens adenylosuccinate lyase (ADSL), transcript variant 1
Alternative NameAMPS; ASASE; ASL
Database LinkNP_000017
Entrez Gene 158 Human
Entrez Gene 315150 Rat
Entrez Gene 709259 Monkey
Entrez Gene 474499 Dog
FunctionAdenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayDruggable Genome Purine metabolismAlanine, aspartate and glutamate metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ADSL (RC200524, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ADSL.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-ADSL monoclonal antibody.
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-ADSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501810)
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HEK293T cells transfected with either RC200524 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-ADSL antibody(TA501810), and then analyzed by flow cytometry.
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