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Anti-PAICS TRUEMAB Antibody Clone OTI1B4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501470 PAICS mouse monoclonal antibody, clone OTI1B4 (formerly 1B4) 100ul
30ul
$325 In Stock
LC416636 PAICS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501470 Carrier-free (BSA/glycerol-free) PAICS mouse monoclonal antibody, clone OTI1B4 (formerly 1B4) 100ug $450 3-4 weeks
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WB(2)
IF(1)
FC(2)
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Also for PAICS (NM_006452)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human PAICS (NP_006443) produced in HEK293T cell.
Clone NameClone OTI1B4 IsotypeIgG2b
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IF, FC Suggested DilutionsWB 1:2000, IF 1:100, FLOW 1:100
Predicted MW Explanation 46.9 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 2
Alternative NameADE2; ADE2H1; AIRC; PAIS
Database LinkNP_006443
Entrez Gene 10606 Human
FunctionThis gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayDruggable Genome Purine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (RC215225, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.
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Western blot analysis of extracts (10ug) from 5 different cell lines by using anti-PAICS monoclonal antibody at 1:200 dilution.
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Anti-PAICS mouse monoclonal antibody (TA501470) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS(RC215225).
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HEK293T cells transfected with either RC215225 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PAICS antibody(TA501470), and then analyzed by flow cytometry.
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Flow cytometric Analysis of Jurkat cells, using anti-PAICS antibody(TA501470),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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